Publications

PLOS ONE
| 10.1371/journal.pone.0309912

2024

Exposure to air pollutants and subclinical carotid atherosclerosis measured by magnetic resonance imaging: A cross-sectional analysis

This paper investigates the association between air pollution exposure, and early markers of carotid atherosclerosis within the Canadian Alliance for Healthy Hearts and Minds Cohort Study. Utilizing MRI to measure carotid vessel volume (CWV), the findings showed no direct association for PM₂.₅, but higher NO₂ was linked to reduced CWV and elevated O₃ to increased CWV. These findings suggest a complex relationship between air pollution and cardiovascular health warranting further research, to uncover underlying mechanisms.
JAMA Network Open
| 10.1001/jamanetworkopen.2021.46324

2022

Evaluation of Adiposity and Cognitive Function in Adults

In this cross-sectional analysis of 9189 adults between 30 and 75 years of age who were free of cardiovascular disease from the Canadian Alliance for Healthy Hearts and Minds (CAHHM) and the Prospective Urban Rural Epidemiological–Mind (PURE-MIND) cohort studies, higher body fat percentage and visceral adipose tissue were associated with more cardiovascular risk factors, vascular brain injuries, and lower cognitive scores.
SSM - Population Health
| 10.1016/j.ssmph.2021.100962

2021

Bonding social capital and health within four First Nations communities in Canada: A cross-sectional study

To date, research on social capital in Indigenous contexts has been scarce. In this quantitative study, our objectives were to (1): Describe bonding social capital within four distinct First Nations communities in Canada, and (2) Explore the associations between bonding social capital and self-rated health in these communities.
BMD Medical Ethics
| 10.1186/s12910-021-00706-3

2021

The Impact Of Reporting Magnetic Resonance Imaging Incidental Findings In The Canadian Alliance For Healthy Hearts And Minds Cohort

In the Canadian Alliance for Healthy Hearts and Minds (CAHHM) cohort, participants underwent magnetic resonance imaging (MRI) of the brain, heart, and abdomen, that generated incidental findings (IFs). The approach to managing these unexpected results remain a complex issue. Our objectives were to describe the CAHHM policy for the management of IFs, to understand the impact of disclosing IFs to healthy research participants, and to reflect on the ethical obligations of researchers in future MRI studies.
Neurology
| 10.1212/WNL.0000000000012765

2021

Effect of Cognitive Reserve on the Association of Vascular Brain Injury With Cognition: Analysis of the PURE and CAHHM Studies

To determine whether cognitive reserve attenuates the association of vascular brain injury with cognition.
IJIH
| 10.32799/ijih.v16i2.33098

2021

Entsisewata’karí:teke (You Will Be Healthy Again): Clinical Outcomes of Returning to a Traditional Haudenosaunee Diet

Haudenosaunee Peoples of eastern North America have a strong agricultural tradition and culture associated with maize horticulture. Traditional foodways and diet were disrupted after the people were dispossessed from traditional lands maintained prior to colonization. As a result, Haudenosaunee have been disconnected from their traditional diet and lifestyle, and chronic diseases such as diabetes and obesity are increasing. Healthy Roots was developed in Six Nations of the Grand River territory by Haudenosaunee community members. It started as a 90-day challenge, in which participants adhere to a diet of traditional foods found in Haudenosaunee territories pre-European contact.
THE JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM
| 10.1210/CLINEM/DGAA815

2021

Diabetes, Brain Infarcts, Cognition, And Small Vessels In The Canadian Alliance For Healthy Hearts And Minds Study

Diabetes is a risk factor for cerebrovascular disease and cognitive impairment. The anatomical basis for this is uncertain.
EUROPEAN HEART JOURNAL. CARDIOVASCULAR IMAGING
| 10.1093/EHJCI/JEZ226

2020

Cardiovascular risk scoring and magnetic resonance imaging detected subclinical cerebrovascular disease

Cardiovascular risk factors are used for risk stratification in primary prevention. We sought to determine if simple cardiac risk scores are associated with magnetic resonance imaging (MRI)-detected subclinical cerebrovascular disease including carotid wall volume (CWV), carotid intraplaque haemorrhage (IPH), and silent brain infarction (SBI).
THE LANCET. PLANETARY HEALTH
| 10.1016/S2542-5196(19)30237-2

2019

Explaining The Variability In Cardiovascular Risk Factors Among First Nations Communities In Canada: A Population-Based Study

Historical, colonial, and racist policies continue to influence the health of Indigenous people, and they continue to have higher rates of chronic diseases and reduced life expectancy compared with non-Indigenous people. We determined factors accounting for variations in cardiovascular risk factors among First Nations communities in Canada.
CJC OPEN
| 10.1016/J.CJCO.2019.09.002

2019

"All About Us": Indigenous Data Analysis Workshop-Capacity Building In The Canadian Alliance For Healthy Hearts And Minds First Nations Cohort

Research collaborations between non-Indigenous and Indigenous researchers primarily have been led by non-Indigenous researchers with privileged locations in university settings. Recognition of the importance of data sovereignty and control to enable Indigenous self-determination requires building data management and analysis capacities among Indigenous research partners. The Canadian Alliance for Healthy Hearts and Minds First Nations (CAHHM-FN) cohort study, a collaboration of 8 First Nations and researchers at 8 universities, convened a 3-day data management and analysis workshop.